Changes in gene expression associated with overexpression of a novel oncogene

ABSTRACT: Oncogenic drivers are still not obvious in a number of human cancers. Identification of oncogenes that contribute to tumorigenic transformation when overexpressed in their wild-type form, either because of gene amplification or due to some other epigenetic changes, is particularly challenging. This study was carried out to understand the gene expression changes associated with overexpression of a novel oncogene, Methyl CpG Binding Protein 2 (MECP2), that we recently uncovered from a genome-scale screen. Immortalized but non-transformed derivatives of human mammary epithelial cells (HMECs) carrying catalytic subunit of human telomerase and SV40 large T and small t antigens, were used as recipient cells for these experiments. We compared changes in gene expression among four different exper

ORGANISM(S): Homo sapiens

SUBMITTER: Manish Neupane 

PROVIDER: E-GEOD-61135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress