Multipotent mammary cancer stem cells integrate stem cell and clonal expansion theories of tumor progression

ABSTRACT: The diversity of human breast cancer subtypes has led to the hypothesis that breast cancer is a number of different diseases arising from cells at various stages of differentiation. We have derived clonal multipotent metastatic mammary cancer stem cells from the polyomavirus middle T mouse model of breast cancer, that can differentiate into luminal, myoepithelial and alveolar cells. When injected orthotopically at low-density, the resulting tumors express estrogen and progesterone receptors. With continued passage in vivo, the tumor cells undergo additional epigenetic and/or genetic changes that result in upregulation of Her2 expression or clonal expansion of cells that give rise to basal-like or claudin-low tumors. As in human tumors, the more aggressive tumor subtypes express nuclear p53

ORGANISM(S): Mus musculus

SUBMITTER: Lesley Ellies 

PROVIDER: E-GEOD-61138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress