Transcriptome analysis of zebrafish heart exposed to sorafenib

ABSTRACT: Sorafenib is associated with cardiac adverse effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish the genes responsible for this cardiotoxicity using zebrafish. A pigmentless zebrafish line expressing green fluorescent protein in the heart were treated with or without sorafenib. In vivo fluorescent cardiac imaging revealed that the ventricular dimension of the longitudinal axis in zebrafish treated with sorafenib was significantly lower than in those without sorafenib. Transcriptome analysis of zebrafish hearts revealed that expression of stanniocalcin1 (stc1) in zebrafish treated with sorafenib was significantly lower than that without sorafenib treatment. We were able to demonstrate that the ventricular dimension of

ORGANISM(S): Danio rerio

SUBMITTER: Yuhei Nishimura 

PROVIDER: E-GEOD-61155 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress