Specific molecular signatures underlie response to decitabine in CMML [ERRBS]

ABSTRACT: Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are used to treat these disorders, but response is highly variable with few means to predict which patients will benefit. To develop a molecular means of predicting response at diagnosis, we examined baseline differences in mutations, DNA methylation, and gene expression in 40 CMML patients responsive and resistant to decitabine (DAC). While somatic mutations did not differentiate responders and non-responders, we were able to identify for the first time 158 differentially methylated regions (DMRs) at baseline between responders and non-responders using next-generation sequencing. These DMRs were p

ORGANISM(S): Homo sapiens

SUBMITTER: Tingting Qin 

PROVIDER: E-GEOD-61161 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress