Distinct EMT programs control normal stem cells and cancer stem cells of mammary tissue

ABSTRACT: Cancer stem cells (CSCs) are proposed to be responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between CSCs and normal tissue stem cells (SC) has led to the notion that CSCs often co-opt the normal SC program of their tissue-of-origin. The cell-biological program termed epithelial-mesenchymal transition (EMT) has been found to encourage entrance of normal and neoplastic mammary cells into the corresponding SC states. Using genetically engineered knock-in reporter mouse lines, we demonstrate that in the murine mammary lineage, the paralogous EMT-inducing transcription factors Snail and Slug, are selectively exploited by CSCs and normal SCs respectively. Slug, when expressed at physiological levels, only activates a partial EMT program and is dis

ORGANISM(S): Mus musculus

SUBMITTER: Xin Ye 

PROVIDER: E-GEOD-61198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress