Gene expression data from 4T1 irradiated tumors treated with TGFbeta blockade

ABSTRACT: Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ, individualized vaccine; however this potential is rarely realized by RT alone. Transforming growth factor β (TGFβ) is an immunosuppressive cytokine that is activated by RT and inhibits the antigen-presenting function of dendritic cells and the differentiation of effector CD8+ T cells. Here we tested the hypothesis that TGFβ hinders the ability of RT to promote anti-tumor immunity. Development of tumor-specific immunity was examined in a pre-clinical model of metastatic breast cancer. Mice bearing established 4T1 mouse mammary carcinoma treated with pan-isoform specific TGFβ neutralizing antibody, 1D11, showed significantly improved control of the irradiated tum

ORGANISM(S): Mus musculus

SUBMITTER: Sandra Demaria 

PROVIDER: E-GEOD-61208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress