Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT

ABSTRACT: Cell plasticity is emerging as a key regulator of tumor progression and metastasis. During carcinoma dissemination epithelial cells undergo epithelial to mesenchymal transition (EMT) processes characterized by the acquisition of migratory/invasive properties, while the reverse, mesenchymal to epithelial transition (MET) process, is also essential for metastasis outgrowth. Different transcription factors, called EMT-TFs, including Snail, bHLH and Zeb families are drivers of the EMT branch of epithelial plasticity, and can be post-transcriptionally downregulated by several miRNAs, as the miR-200 family. The specific or redundant role of different EMT-TFs and their functional interrelations are not fully understood. To study the interplay between different EMT-TFs, comprehensive gain and loss

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Gema Moreno-Bueno 

PROVIDER: E-GEOD-61217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress