Expression data from yeast heterologously expressing alpha-ENaC, CFTR or Kir2.1 [CFTR]

ABSTRACT: Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and are subject to the ER associated degradation pathway, which clears the secretory pathway of potentially toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited data exist describing the cellular response to misfolded membrane proteins. To this end, we expressed and then compared the transcriptional profiles elicited by the synthesis of three ER retained, misfolded ion channels: The α subunit of the epithelial sodium channel, ENaC, the cystic fibrosis transmembrane conductance regulator, CFTR, and an inwardly rectifying potassium channel, Kir2.1, which vary in their mass, membrane topologies, and quaternary structures. To examine transcriptional profi

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Teresa Buck 

PROVIDER: E-GEOD-61244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress