Novel bio-marker discovery for stratification and prognosis of breast cancer patients

ABSTRACT: The study entails novel bio-marker discovery of Tumor Aggressive Grade signature (TAGs) genes and their role in recurrence free survival of breast cancer (BC) patients. Current BC dataset was used for co-expression analysis of TAGs genes and their role in BC progression. Additionally, recent findings have suggested an importance of structural organization of sense-antisense gene pairs (SAGPs) for transcription, post-transcriptional and post-translational events and their associations with cancer and disease. We studied SAGPs in which both gene partners are protein encoding genes (coding-coding SAGPs, ccSAGPs), their role in human BC development and demonstrated their potential for BC stratification and prognosis. Based on gene expression and correlation analyses we identified the robust s

ORGANISM(S): Homo sapiens

SUBMITTER: Surya Pavan Yenamandra 

PROVIDER: E-GEOD-61304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress