Radiation-Induced T Cell Lymphoma: Carbon ion- vs. Gamma Ray-Induced

ABSTRACT: Here, male and female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at the Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour volume. These mice were then monitored for the remainder of their lifespan and a large number of T cell lymphomas were analysed, alongside those arising in mice exposed to equivalent doses of standard Cs137 gamma ray-irradiation. Using genome-wide DNA copy number analysis to identify genomic loci involved in radiation-induced lymphomagenesis and subsequent detailed analysis of Notch1, Ikaros, Pten, Trp53 and Bcl11b genes we compared the genetic profile of the carbon ion- and gamma ray-induced tumours. The canonical set

ORGANISM(S): Mus musculus

SUBMITTER: Benjamin Blyth 

PROVIDER: E-GEOD-61315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress