Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci

ABSTRACT: Recent meta-analyses of genome wide association studies (GWAS) have identified approximately 150 loci that are associated with coronary artery disease (CAD). To link the causal genes in these loci to functional transcriptional networks, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with human coronary artery smooth muscle cells (HCASMC) to investigate the cellular and molecular program downstream of one CAD associated transcription factor, TCF21. Analysis of the TCF21 downstream target genes for enrichment of molecular and cellular annotation terms identified processes relevant to CAD pathophysiology, including growth factor binding (PDGF, VEGF), matrix interactions (“integrin binding,” “cell adhesion”), and smooth muscle contraction (“actin filament-based processes,” “a

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Quertermous 

PROVIDER: E-GEOD-61369 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress