Hepatitis B virus pre-S2 mutant LHBS induced DNA breakages and genomic instability.

ABSTRACT: Although hepatitis B virus (HBV) has been established to cause hepatocellular carcinoma (HCC), the exact mechanism remains to be clarified. Type II ground glass hepatocytes (GGH) harboring the HBV pre-S2 mutant large surface protein have been recognized as morphologically distinct hallmark of HCC in advanced stages of chronic HBV infection. Considering its pre-neoplastic nature, we hypothesized that type II GGH may exhibit high genomic instability, which is important for the carcinogenic process in chronic HBV carriers. In this study we found that pre-S2 mutant LHBS directly interacted with importin 1, the key factor that recognizes cargos undergoing nuclear transportation mediated by the importin 1 associated nuclear pore complex (NPC). By interacting with importin 1, which inhibits its f

ORGANISM(S): Mus musculus

SUBMITTER: Wenya Huang 

PROVIDER: E-GEOD-61378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress