Identification of candidate rhinovirus C (RV-C) receptors by gene expression analysis

ABSTRACT: Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared to other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We measured gene expression (Human Gene 1.0 ST Array, Affymetrix) in two series of experiments involving cells that were either susceptible or not susceptible to RV-C infection. In one experimental series, susceptible cells included whole sinus mucosal tissue specimens (n = 5), epithelial cell suspension from sinus tissue, and nasal epithelium obtained via brushing, while non-susceptible cells included monolayers of primary undifferentiated epithelial cells and transformed cell lines (n = 5). In a second experimental series, we compared three pairs of undifferentiated and fully differentia

ORGANISM(S): Homo sapiens

SUBMITTER: Yury Bochkov 

PROVIDER: E-GEOD-61396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress