Progesterone-mediated effects on gene expression in mouse fallopian tube

ABSTRACT: The fallopian tube transports the gametes to the fertilization site and delivers the embryo to the uterus at the optimal time for implantation. Progesterone and the classical progesterone receptor (PGR) are known to be involved in regulating both tubal ciliary beating and muscular contractions, possibly involving both genomic and non-genomic actions. To provide more clues on the mechanisms involved, we investigated the effect of progesterone on gene expression in mice fallopian tubes in vitro at early (20 min) and later (2 h, 8 h) time-points using microarray and/or quantitative PCR. In parallel, oocyte cumulus complex transport was investigated in ovulating mice injected with one of the PGR antagonists, Org 31710 or CDB2194. Microarray analyses did not reveal any apparently regulated g

ORGANISM(S): Mus musculus

SUBMITTER: Anna Bylander 

PROVIDER: E-GEOD-61407 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress