Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

10 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PSMAD1/5/8 ChIP-Seq in hair follicle stem cell lineage

ABSTRACT: We performed ChIP_Seq on purified hair follicle stem cells (HFSCs)and their direct progenty, transit amplifying cells (TACs) using and antibody against pSMAD1/5/8. We report novel common and unique in vivo pSMAD targets for each population. Examination of pSMAD1/5/8 targets in a stem cell lineage

ORGANISM(S): Mus musculus

SUBMITTER: Maria Genander

PROVIDER: E-GEOD-61430 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

pSMAD1/5/8 ChIP-Seq in hair follicle stem cell lineage

Project description:We performed ChIP_Seq on purified hair follicle stem cells (HFSCs)and their direct progenty, transit amplifying cells (TACs) using and antibody against pSMAD1/5/8. We report novel common and unique in vivo pSMAD targets for each population.

2014-09-30 | GSE61430 | GEO

BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-30 | E-GEOD-61506 | biostudies-arrayexpress

RNA-Seq in hair follicle stem cell lineage

Project description:We performed RNA_Seq on purified hair follicle stem cells (HFSCs)and their direct progenty, transit amplifying cells (TACs) using temorally and spatially regulated Cre lines.

2014-09-30 | GSE61505 | GEO

RNA-Seq in hair follicle stem cell lineage

Project description:We performed RNA_Seq on purified hair follicle stem cells (HFSCs)and their direct progenty, transit amplifying cells (TACs) using temorally and spatially regulated Cre lines. Consequences of loss of Bmpr1a in either HFSC (K15-CrePGR;Bmpr1a fl/fl), or TACs (1. Shh-CreER:Bmpr1a fl/fl or 2. K15-CrePGR;Bmpr1a fl/fl derived)

2014-09-30 | E-GEOD-61505 | biostudies-arrayexpress

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

Project description:Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs) and transit-amplifying cells (TACs). We used ChIP-seq to unfold genome-wide chromatin landscapes of H3K27ac and Med1 to identify super-enhancers and dissect their biological relevance in cell identity and plasticity of HFSCs in vivo and in vitro.

2015-03-19 | GSE61316 | GEO

Nfatc1 Orchestrates Aging in Hair Follicle Stem Cells

Project description:Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quiescent hair follicle stem cells (HFSCs) were FACS-purified for ChIP-sequcencing.

2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress

Architectural niche organization by LHX2 is linked to hair follicle stem cell function

Project description:To identify direct LHX2 target genes in HFSCs, we performed chromatin immunoprecipitation and deep sequencing (ChIP-seq) analysis using FACS-isolated HFSCs. Three independent LHX2 ChIP-seq experiments were conducted.

2013-09-05 | E-GEOD-48068 | biostudies-arrayexpress

Architectural niche organization by LHX2 is linked to hair follicle stem cell function

Project description:To identify direct LHX2 target genes in HFSCs, we performed chromatin immunoprecipitation and deep sequencing (ChIP-seq) analysis using FACS-isolated HFSCs.

2013-09-05 | GSE48068 | GEO

Signaling couples hair follicle stem cell quiescence with reduced histone H3K4/K9/K27me3 for proper tissue homeostasis

Project description:Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T cell progenitors. We used mouse hair follicle stem cells (HFSCs) at two different hair cycle stages (early anagen and late catagen) to compare the genome-wide changes in the levels of histone modification marks H3K4me3, H3K9me3, and H3K27me3. Hair follicle stem cells from Early Anagen (EA-HFSCs) and Late Catagen (LC-HFSCs), and their non-HFSCs counterparts (nEA-HFSCs and nLC-HFSCs), were FACS-isolated for Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) analysis of H3K4me3, H3K9me3, and H3K27me3.

2016-04-13 | E-GEOD-78749 | biostudies-arrayexpress

Polycomb repressive complex 2 (PRC2) function in adult hair follicle stem cells is dispensable for hair regenration

Project description:Polycomb repressive complexes 2 mediated gene regulation in adult HFSCs is non-instructive for hair regenration

2021-11-17 | GSE172082 | GEO