Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

ABSTRACT: Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development. Results: We profile methylomic variation in matched prefrontal cortex and cerebellum brain tissue from schizophrenia patients and controls, identifying disease-associated differential DNA methylation at multiple loci, particularly in the prefrontal cortex, and confirming these differences in an independent set of adult b

ORGANISM(S): Homo sapiens

SUBMITTER: Leonard Schalkwyk 

PROVIDER: E-GEOD-61431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress