Microarray analysis to evaluate the role of USP18 in primary microglia and the microglia cell line BV-2

ABSTRACT: Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, called ‘microgliopathies’. However, how the intracellular stimulation machinery in microglia is controlled is poorly understood. By using expression studies, we identified the ubiquitin-specific protease (Usp) 18 in white matter microglia that essentially contributes to microglial quiescence under homeostatic conditions. We further found that microglial Usp18 negatively regulated the activation of STAT1 and concomitant induction of interferon-induced genes thereby disabling the termination of IFN sig

ORGANISM(S): Mus musculus

SUBMITTER: Ori Staszewski 

PROVIDER: E-GEOD-61500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress