A functional portrait of Med7 and the Mediator complex in Candida albicans [ChIP-chip]

ABSTRACT: In this study, we have investigated Mediator function in the human fungal pathogen C. albicans. An initial screening of conditionally regulated Mediator subunits showed that the Med7 of C. albicans was not essential, in contrast to the situation noted for Saccharomyces cerevisiae. While loss of CaMed7 did not lead to loss of viability under normal growth conditions, it dramatically influenced the pathogenM-bM-^@M-^Ys ability to grow in different carbon sources, to form hyphae and biofilms, and to colonize the gastrointestinal tracts of mice. We used location profiling to determine Mediator binding under yeast and hyphal morphologies characterized by different transcription profiles. We observed a core set of specific and common genes bound by Med7 under both conditions; this specific core

ORGANISM(S): Candida albicans

SUBMITTER: Faiza Tebbji 

PROVIDER: E-GEOD-61518 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress