Plasmodium parasites mount an arrest response against dihydroartemisinin [Microarray]

ABSTRACT: Control of malaria is threatened by emerging parasite resistance to artemisinin drug (ART) therapies. The molecular details of how Plasmodium malaria parasites response to ART and how this relates to resistance is not clear. To determine how parasites respond to ART by altering gene expression, we performed a transcriptomic study of dihydroartemisinin (DHA) response in P. falciparum K1 strain and in P. berghei ANKA strain. Microarray data from DHA-treated P. falciparum trophozoite stage parasites were compared with data from other ART treatments. Genes with consistent changes in expression were identified, which includes notably down-regulation of cytosolic ribosomal protein genes. RNA-seq data revealed a similar pattern of transcriptomic change, although the pattern was much clearer in t

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Philip Shaw 

PROVIDER: E-GEOD-61536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress