Transcriptional profile of the abdomen of zebrafish deiodinase knockdown

ABSTRACT: The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome, biochemistry, morphology and physiology using morpholino (MO) knockdown. Knockdown of D1+D2 (D1D2MO) and knockdown of D3 (D3MO) both resulted in transcriptional regulation of metabolism and (muscle) development in abdomen and tail, together with reduced growth, impaired swim bladder inflation, reduced protein content and reduced motility. The reduced growth and impaired swim bladder inflation in D1D2MO could be due to lower levels of T3 which is known to drive growth and development. The pronounced upregulation of a large number of

ORGANISM(S): Danio rerio

SUBMITTER: Lucia Vergauwen 

PROVIDER: E-GEOD-61623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress