Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Bruno Paiva
PROVIDER: E-GEOD-61650 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20150205 15
Although information about the molecular pathogenesis of Waldenström macroglobulinemia (WM) has significantly advanced, the precise cell of origin and the mechanisms behind WM transformation from immunoglobulin-M (IgM) monoclonal gammopathy of undetermined significance (MGUS) remain undetermined. Here, we undertook an integrative phenotypic, molecular, and genomic approach to study clonal B cells from newly diagnosed patients with IgM MGUS (n = 22), smoldering (n = 16), and symptomatic WM (n = 1 ...[more]