Transcription profile of pho85 damp strain during growth in no phosphate medium

ABSTRACT: Depletion of essential nutrients triggers regulatory programs that prolong cell growth and survival. Starvation-induced processes increase nutrient transport, mobilize nutrient storage, and recycle nutrients between cellular components. This leads to an effective increase in intracellular nutrients, which may act as a negative feedback that down-regulates the starvation program. To examine how cells overcome this potential instability, we followed the transcription response of budding yeast transferred to medium lacking phosphate. Genes were induced in two temporal waves. The first wave was stably maintained and persisted even upon phosphate replenishment, indicating a positive feedback loop. This commitment was abolished after two hours with the induction of the second expression wave, c

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Noam Vardi 

PROVIDER: E-GEOD-61663 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress