Impact of regulatory variation from mRNA to protein

ABSTRACT: Genetic variants that impact gene regulation are important contributors to human phenotypic variation. For this reason, considerable efforts have been made to identify genetic associations with differences in mRNA levels of nearby genes, namely, cis expression quantitative trait loci (eQTLs). The phenotypic consequences of eQTLs are presumably due, in most cases, to their ultimate effects on protein expression levels. Yet, only few studies have quantified the impact of genetic variation on proteins levels directly. It remains unclear how faithfully eQTLs are reflected at the protein level, and whether there is a significant layer of cis regulatory variation acting primarily on translation or steady state protein levels. To address these questions, we measured ribosome occupancy by high-thr

ORGANISM(S): Homo sapiens

SUBMITTER: Sidney Wang 

PROVIDER: E-GEOD-61742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress