Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Rat Semi-Circular Canal Duct Gene Expression Studies

ABSTRACT: The goal was to screen for the expressed genes in Semi-Circular Canal Duct (SCCD) that are related to ion transport and its regulation. The objective was to discover which genes changed expression levels in response to glucocorticoids. Keywords: drug response Primary cultures were incubated for 24 hours in the presence or absence of 100 nM dexamethasone. Four independent cultures from each group were processed for total RNA and submitted for gene array analysis. Although two Samples out of four in each group were done at different time points, we found that there was not much variation between the datasets (by cluster analysis).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daniel Marcus

PROVIDER: E-GEOD-6197 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium.

Pondugula Satyanarayana R SR Raveendran Nithya N NN Marcus Daniel C DC

BMC research notes 20100414

<h4>Background</h4>The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracrine and autocrine hormones along with their associated intracellular signal pathways. The epithelium lining the semicircular canal duct (SCCD) is a tissue that is known to absorb sodium and calcium and to secrete chloride.<h4>Findings</h4>Transport function was assessed b ...[more]

PMID: 20398257

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Dataset Information

Rat Semi-Circular Canal Duct Gene Expression Studies

Publications

Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium.

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