RNA-sequencing of the GSI treatment of the CUTLL1 cell line

ABSTRACT: Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T-cell acute lymphoblastic leukemias, supporting an essential driver role for this gene in T-cell acute lymphoblastic leukemia oncogenesis. In this study, we aimed to establish a comprehensive compendium of the long non-coding RNA transcriptome under control of Notch signaling. For this purpose, we measured the transcriptional response of all protein coding genes and long non-coding RNAs upon pharmacological Notch inhibition in the human T-cell acute lymphoblastic leukemia cell line CUTLL1 using

ORGANISM(S): Homo sapiens

SUBMITTER: Annelynn Wallaert 

PROVIDER: E-GEOD-61999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress