The DNMT1 associated lncRNA Dali is an epigenetic regulator of neural differentiation [4]

ABSTRACT: Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate transcription by modulating chromatin at genomically distant loci. Here, we report both genomically local and distal RNA-dependent roles of Dali, a conserved central nervous system expressed intergenic lncRNA. Dali is transcribed downstream of the Pou3f3 transcription factor gene and its depletion disrupts the differentiation of neuroblastoma cells. Locally, Dali transcript regulates transcription of the Pou3f3 locus. Distally, it preferentially targets active promoters and regulates expression of neural differentiation genes, in part through physical association with the POU3F3 protein. Dali interacts with the DNMT1 DNA methy

ORGANISM(S): Mus musculus

SUBMITTER: Vladislava Chalei 

PROVIDER: E-GEOD-62034 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress