Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MRNA Expression Changes Induced by Myocardial MCU Inhibition

ABSTRACT: Mitochondrial calcium is an important second-messenger controlling fight-or-flight responses in the heart. The molecular identity of MCU (Mitochondrial Calcium Uniporter) was recently discovered allowing us to test this hypothesis in vivo by expressing a myocardial delimited dominant negative form of MCU. We queried mRNA expression changes induced by dominant negative MCU expression in the heart. Neonatal (< 24 h) and 6 week old hearts were harvested from mice expressing the dominant negative MCU construct or wild-type littermates.

ORGANISM(S): Mus musculus

SUBMITTER: Tyler Rasmussen

PROVIDER: E-GEOD-62049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Rasmussen Tyler P TP Wu Yuejin Y Joiner Mei-ling A ML Koval Olha M OM Wilson Nicholas R NR Luczak Elizabeth D ED Wang Qinchuan Q Chen Biyi B Gao Zhan Z Zhu Zhiyong Z Wagner Brett A BA Soto Jamie J McCormick Michael L ML Kutschke William W Weiss Robert M RM Yu Liping L Boudreau Ryan L RL Abel E Dale ED Zhan Fenghuang F Spitz Douglas R DR Buettner Garry R GR Song Long-Sheng LS Zingman Leonid V LV Anderson Mark E ME

Proceedings of the National Academy of Sciences of the United States of America 20150707 29

Myocardial mitochondrial Ca(2+) entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca(2+) are lacking. We developed a mouse model with myocardial delimited transgenic expression of a dominant negative (DN) form of the mitochondrial Ca(2+) uniporter (MCU). DN-MCU mice lack MCU-mediated mitochondrial Ca(2+) entry in myocardium, but, surprisingly, isolated perfused hearts exhibited high ...[more]

Dataset Information

MRNA Expression Changes Induced by Myocardial MCU Inhibition

Publications

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

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