A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas

ABSTRACT: The inherent diagnostic limitations of thyroid fine needle aspiration (FNA), especially in the “indeterminate” category, can be partially overcome by molecular analyses. We aimed at the identification of miRNAs that could be used to improve the discrimination of indeterminate FNAs. miRNA expression profiling was performed for 17 follicular carcinomas (FTCs) and 8 follicular adenomas (FAs). The microarray results underwent cross-comparison using three additional microarray data sets. Candidate miRNAs were validated by qPCR in an independent set of 32 FTCs and 46 FAs. Sixty-eight differentially expressed miRNAs were identified. Thirteen miRNAs could be confirmed by cross comparison. A two-miRNA-classifier was established improving the diagnostic applicability and resulted in a sensiti

ORGANISM(S): Homo sapiens

SUBMITTER: Tomasz Stokowy 

PROVIDER: E-GEOD-62054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress