Transcription profiling of rat kidney from dahl salt-sensitive (S) and the renal protective S.SHR(2) congenic strain

ABSTRACT: The study sought to investigate differences in onset and progression of renal disease in the Dahl salt-sensitive (S), S.SHR(2) congenic, and spontaneously hypertensive rat (SHR) using a time-course. The data clearly demonstrates that the locus on chromosome 2 has a major and sustained ability to attenuate renal damage. As early as week 4, significant interstitial changes were observed between the S and the congenic which preceded any significant difference in proteinuria. Gene expression profiling was performed at week 4, 12, and 20 using kidney from the S and S.SHR(2) congenic to: (1) identify expression differences of positional candidates within the QTL region; (2) correlate temporal gene expression changes between the S and congenic with degree of renal damage; and (3) identify biochem

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Garrett 

PROVIDER: E-GEOD-6208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress