Co-expression network analysis from genes involved with neural-differentiation shows specific pattern in patients with schizophrenia

ABSTRACT: Schizophrenia is a severe and debilitating neuropsychiatric disorder with the involvement of genetic and environmental factors contributing to its pathogenesis. The specific role of the brain cell types in the disease remains uncovered due to the difficulties in accessing diseased tissue. This study analysed molecular alterations in human induced pluripotent stem cells derived from fibroblasts from control subject and individual with schizophrenia and further differentiated to neuron to identify genes relevant for the development of schizophrenia. We identified 228 genes that are involved with metabolic processes, signal transduction, nervous system development, regulation of neurogenesis and neuronal differentiation. These genes were analysed in expression microarrays of post-mortem brain

ORGANISM(S): Homo sapiens

SUBMITTER: Renato Puga 

PROVIDER: E-GEOD-62105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress