Validation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population

ABSTRACT: Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to predict metastasis, newer risk prediction models are needed. We report a validation study of a genomic classifier that predicts metastasis after radical prostatectomy in a high risk population. Method:A case-cohort design was used to sample 1,010 patients after radical prostatectomy at high risk for recurrence who were treated from 2000 to 2006. Patients had preoperative prostate specific antigen greater than 20 ng/ml, Gleason 8 or greater, pT3b or a Mayo Clinic nomogram score of 10 or greater. P

ORGANISM(S): Homo sapiens

SUBMITTER: Elai Davicioni 

PROVIDER: E-GEOD-62116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress