Differential adipose tissue gene expression profiles in abacavir treated patients that may contribute to cardiovascular risk: a microarray study

ABSTRACT: Objective: to compare changes in gene expression by microarray from subcutaneous adipose tissue from HIV treatment naïve patients treated with efavirenz based regimens containing abacavir (ABC), tenofavir (TDF) or zidovidine (AZT). There were significant divergence between ABC and the other two groups 6 months after treatment in genes controlling cell adhesion and environmental information processin, with some convergence at 18 months. Compared to HIV negative controls the ABC group, but not AZT or TDF, showed enrichment of genes controlling adherence junction at six months and 184 months (adjusted p <0.05), and cell matrix adhesion (adjusted p<3.4E-0.5) at 6 months. Tight junction (p=0.03), gap junction (p<0.05) and leukocyte transendothelial migration (p=0.03) were over-expressed in ABC

ORGANISM(S): Homo sapiens

SUBMITTER: Mohsen Shahmanesh 

PROVIDER: E-GEOD-62117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress