Time dynamics of quantitative protein and mRNA levels reveals extensive translational regulation after stress

ABSTRACT: Eukaryotic cells are constantly challenged by the presence of reactive oxygen species, which play an important role in aging and human disease progression. In particular, acute oxidative stress can lead to extensive damage to cellular DNA, proteins, and lipids and can trigger a response that remodels the transcriptional and translational state of the cell. Although a number of previous studies have profiled the relative changes in mRNA and protein and more studies revealing the dynamics of transcription and translation in response to stress are starting to emerge, a quantitative view of this response has been lacking. Here, we have applied quantitative methods to characterize the time dynamics of mRNA and protein levels in the oxidative stress response of the fission yeast Schizosaccharomy

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Federico De Masi 

PROVIDER: E-GEOD-62120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress