Global identification of the gene networks and cis-regulatory elements of the cold response in zebrafish

ABSTRACT: The transcriptional programs of ectothermic teleosts are directly influenced by water temperature. Although various cold-responsive transcriptional patterns have been determined in fishes, the systematic molecular networks governing the temperature responses are still unknown. We profiled the transcriptional responses in eight tissues of zebrafish exposed to graded cold temperatures, ranging from normal (28°C) to mild (18°C) and severe (10°C) cold, using RNA-seq. The tissues varied in the number of cold-responsive genes, of which the kidney appeared to be most sensitive, whereas the brain was the least. Fuzzy k-means clustering revealed 34 gene clusters of distinct expression patterns, demonstrating diverse tissue-specific responses in conjunction with multiple aspects of ubiquitous cross-

ORGANISM(S): Danio rerio

SUBMITTER: Peng Hu 

PROVIDER: E-GEOD-62221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress