Unknown,Transcriptomics,Genomics,Proteomics

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Specific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133B]


ABSTRACT: To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. The identified genes are specific to colon cancer and hepatic metastases since other metastatic locations and hepatic metastases originating from breast cancer were not classified by the signature. Gene Ontology term analysis showed that 50% of the genes are implicated in extracellular matrix remodeling, and more precisely in cell adhesion, extracellular matrix organization and angiogenesis. Because of the high efficiency of the signature to classify colon hepatic metastases, the identified genes represent promising targets to develop new therapies that will specifically affect hepatic metastasis microenvironment. 57 samples of patients with stage IV colorectal cancer. We compared using Affymetrix chips gene expression profiles between primary tumors and hepatic metastases

ORGANISM(S): Homo sapiens

SUBMITTER: Pierre Martineau 

PROVIDER: E-GEOD-62321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan.

Del Rio Maguy M   Molina Franck F   Bascoul-Mollevi Caroline C   Copois Virginie V   Bibeau Frédéric F   Chalbos Patrick P   Bareil Corinne C   Kramar Andrew A   Salvetat Nicolas N   Fraslon Caroline C   Conseiller Emmanuel E   Granci Virginie V   Leblanc Benjamin B   Pau Bernard B   Martineau Pierre P   Ychou Marc M  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070301 7


<h4>Purpose</h4>In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major clinical challenge is to identify the subset of patients who could benefit from this chemotherapy. We aimed to identify a gene expression profile in primary colon cancer tissue that co  ...[more]

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