The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

ABSTRACT: Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow precursor that differentiates into all known ILC lineages. NFIL3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of CLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the CLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX

ORGANISM(S): Mus musculus

SUBMITTER: Lora Hooper 

PROVIDER: E-GEOD-62337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress