Post-natal development of brown adipocytes in white fat: Phases independent and dependent of the ambient temperature

ABSTRACT: Decreased ambient temperature, from birth to weaning, significantly reduced fat mass (FM) and adiposity in developing mice. Changes in FM content in 10 day-old mice raised at 17°C were not accompanied by precocious induction of brown adipocytes in inguinal white adipose tissue (WAT). Brown phenotype was induced in 21 day-old mice independently of ambient temperature (17°C or 29°C) however the expression of Ucp1 and other brown fat biomarker genes was greater in animals raised at 17°C suggesting increased adaptive thermogenesis. Accordingly, we predict that the induction of brown adipocytes in WAT follows a strict developmental program and the number of potential brown adipocytes in WAT is determined genetically. Microarray analysis of gene expression was performed on inguinal white adipose

ORGANISM(S): Mus musculus

SUBMITTER: Monika Kaczmarek 

PROVIDER: E-GEOD-62350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress