In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration (array)

ABSTRACT: Heart failure is a leading cause of mortality and morbidity in the developed world, partly because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary loss of regenerative mechanisms present in other organisms or to an inability to activate such mechanisms is currently unclear. Here, we decipher mechanisms underlying heart regeneration in adult zebrafish and show that the molecular regulators of this response are conserved in mammals. We identified miR-99/100 and Let-7a/c, and their protein targets smarca5 and fntb, as critical regulators of cardiomyocyte dedifferentiation and heart regeneration in zebrafish. Although human and murine adult cardiomyocytes fail to elicit an endogenous regenerative response following myocardial infarction, we show that in

ORGANISM(S): Danio rerio

SUBMITTER: Christopher Benner 

PROVIDER: E-GEOD-62386 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress