Expression data from two sorted lymphatic endothelial cell (LEC) populations, podoplanin-high versus podoplanin low

ABSTRACT: Extracorporeal shockwave treatment was shown to improve orthopaedic diseases, wound healing and to stimulate lymphangiogenesis in vivo. The aim of this study was to investigate in vitro shockwave treatment (IVSWT) effects on lymphatic endothelial cell (LEC) behavior and lymphangiogenesis. We analyzed migration, proliferation, vascular tube forming capability and marker expression changes of LECs after IVSWT compared with HUVECs. Finally, transcriptome- and miRNA analyses were conducted to gain deeper insight into the IVSWT-induced molecular mechanisms in LECs. The results indicate that IVSWT-mediated proliferation changes of LECs are highly energy flux density-dependent and LEC 2D as well as 3D migration was enhanced through IVSWT. IVSWT suppressed HUVEC 3D migration but enhanced vasculoge

ORGANISM(S): Homo sapiens

SUBMITTER: Bernhard Schweighofer 

PROVIDER: E-GEOD-62510 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress