C-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Corey
PROVIDER: E-GEOD-62514 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.
Kwan Kelvin Y KY Shen Jun J Corey David P DP
Stem cell reports 20141211 1
Sensorineural hearing loss is caused by the loss of sensory hair cells and neurons of the inner ear. Once lost, these cell types are not replaced. Two genes expressed in the developing inner ear are c-Myc and Sox2. We created immortalized multipotent otic progenitor (iMOP) cells, a fate-restricted cell type, by transient expression of C-MYC in SOX2-expressing otic progenitor cells. This activated the endogenous C-MYC and amplified existing SOX2-dependent transcripts to promote self-renewal. RNA- ...[more]
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