Gene expression profiles in dorsal skin of hairless mice orally administrated collagen hydrolysate for 12 weeks

ABSTRACT: Dietary collagen hydrolysate has been conjectured to improve skin barrier function. To investigate the effect of long-term collagen hydrolysate administration on the skin, we evaluated stratum corneum water content and skin elasticity in intrinsic aged mice. Female 9-week-old hairless mice were fed a control diet, or a collagen hydrolysate-containing diet, for 12 weeks. The stratum corneum water content and skin elasticity were sequentially decreased by chronological aging in control mice. Intake of collagen hydrolysate significantly suppressed such changes. Moreover, we comprehensively analyzed gene expression in the skin of mouse, which had been administered collagen hydrolysate, using DNA microarray. Twelve weeks after start of collagen intake, no significant differences appeared in gen

ORGANISM(S): Mus musculus

SUBMITTER: Yuji Nakai 

PROVIDER: E-GEOD-62649 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress