Mutant p53 in fallopian tube epithelium and high-grade serous cancer formation

ABSTRACT: Ovarian cancer is the fifth leading cause of cancer death among US women. Evidence supports the hypothesis that high-grade serous ovarian cancers (HGSC) may originate in the distal end of the fallopian tube. Although a heterogeneous disease, 96% of HGSC contain mutations in p53. In addition, the “p53 signature”, or overexpression of p53 protein (usually associated with mutation), is a potential precursor lesion of fallopian tube derived HGSC suggesting an essential role for p53 mutation in early serous tumorigenesis. To further clarify p53-mutation dependent effects on cells, murine oviductal epithelial cells (MOE) were stably transfected with a construct encoding for the R273H DNA binding domain mutation in p53, the most common mutation in HGSC. Mutation in p53 was not sufficient to tr

ORGANISM(S): Mus musculus

SUBMITTER: Joanna Burdette 

PROVIDER: E-GEOD-62694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress