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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-seq for IRF7

ABSTRACT: We performed ChiP-Seq for IRF7 in GM-CSF induced bone-marrow cells. IRF7 ChIP-Seq in myeloid cells

ORGANISM(S): Mus musculus

SUBMITTER: Ido Amit

PROVIDER: E-GEOD-62697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner.

Cohen Merav M Matcovitch Orit O David Eyal E Barnett-Itzhaki Zohar Z Keren-Shaul Hadas H Blecher-Gonen Ronnie R Jaitin Diego Adhemar DA Sica Antonio A Amit Ido I Schwartz Michal M

The EMBO journal 20141110 24

Tissue microenvironment influences the function of resident and infiltrating myeloid-derived cells. In the central nervous system (CNS), resident microglia and freshly recruited infiltrating monocyte-derived macrophages (mo-MΦ) display distinct activities under pathological conditions, yet little is known about the microenvironment-derived molecular mechanism that regulates these differences. Here, we demonstrate that long exposure to transforming growth factor-β1 (TGFβ1) impaired the ability of ...[more]

PMID: 25385836

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