Spinal cord injury (RNA sequencing data)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ido Amit
PROVIDER: E-GEOD-62698 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner.
Cohen Merav M Matcovitch Orit O David Eyal E Barnett-Itzhaki Zohar Z Keren-Shaul Hadas H Blecher-Gonen Ronnie R Jaitin Diego Adhemar DA Sica Antonio A Amit Ido I Schwartz Michal M
The EMBO journal 20141110 24
Tissue microenvironment influences the function of resident and infiltrating myeloid-derived cells. In the central nervous system (CNS), resident microglia and freshly recruited infiltrating monocyte-derived macrophages (mo-MΦ) display distinct activities under pathological conditions, yet little is known about the microenvironment-derived molecular mechanism that regulates these differences. Here, we demonstrate that long exposure to transforming growth factor-β1 (TGFβ1) impaired the ability of ...[more]
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