Functions of BET proteins in GATA1-mediated transcription
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Aaron Stonestrom
PROVIDER: E-GEOD-62737 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Functions of BET proteins in erythroid gene expression.
Stonestrom Aaron J AJ Hsu Sarah C SC Jahn Kristen S KS Huang Peng P Keller Cheryl A CA Giardine Belinda M BM Kadauke Stephan S Campbell Amy E AE Evans Perry P Hardison Ross C RC Blobel Gerd A GA
Blood 20150218 18
Inhibitors of bromodomain and extraterminal motif proteins (BETs) are being evaluated for the treatment of cancer and other diseases, yet much remains to be learned about how BET proteins function during normal physiology. We used genomic and genetic approaches to examine BET function in a hematopoietic maturation system driven by GATA1, an acetylated transcription factor previously shown to interact with BETs. We found that BRD2, BRD3, and BRD4 were variably recruited to GATA1-regulated genes, ...[more]
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