Twist1 knockdown in two gastric cancer-associated fibroblast lines

ABSTRACT: Primary human gastric cancer-associated fibroblast (CAF) cultures (CAF14 and CAF32) were establised from 2 gastrectomy specimens. Silencing the expression (loss-of-function effect) of Twist1 in CAFs showed candidate target genes regulated by Twist1 and abrogated their tumor-promoting properties. Experiment design: two gastric CAFs (CAF14 adn CAF32, respectively) were establised from two gastric cancer patients and Twist1 knockdown studies were performed using shRNA.

ORGANISM(S): Homo sapiens

SUBMITTER: Chang Ohk Sung 

PROVIDER: E-GEOD-62738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress