Hepatic gene expression in C56BL/6J mice fed a quercetin diet for 20 weeks

ABSTRACT: Both the 0.05% and 1% querceitn diets did not significantly affect the body weight, fat accumulation, and blood components. However, 0.05% quercetin significantly increased the glutathione/oxidized glutathione ratio in the liver. Moreover, the 1% quercetin diet reduced the lipid peroxidation markers 8-isoprostane in plasma and malondialdehyde in the liver, epididymal adipose tissues, and small intestine. Although comprehensive gene expression analysis dot not detect the genes with significantly different expression levels among the groups of mice, RT-PCR analysis showed that the 1% quercetin diet significantly induced the expression of the antioxidant enzymes Gpx1, Cat, and Sod1 in the liver and Gpx1 and Cat in the epididymal adipose tissues. The transcription factor nuclear factor E2-rela

ORGANISM(S): Mus musculus

SUBMITTER: Masuko Kobori 

PROVIDER: E-GEOD-62805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress