MicroRNA Profiling Analysis and Target Gene Prediction in Laryngeal Squamous Cell Carcinoma

ABSTRACT: Objective: The purpose of this study was to investigate the miRNAs basis of tumorigenesis in LSCC, and analyze the physiological processes of target genes predicted by the screened miRNAs that may be useful for the effective therapeutic strategies. Methods: A total number of 6 patients who underwent surgery for primary laryngeal squamous cell carcinoma were recruited for miRNA array analysis. LSCC tissues compared with corresponding adjacent non-neoplastic tissues were analysed by the Affymetrix GeneChip miRNA Array 3.0 to screen effective miRNAs, then TargetScan,PITA and microRNAorg were used for target gene prediction in GeneSpring 12.5 software.Moreover, pathway-based methods were adopted to analyse physiological processes of the target genes. The screened miRNAs and the significant tar

ORGANISM(S): Homo sapiens

SUBMITTER: Jugao Fang 

PROVIDER: E-GEOD-62819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress