EIF4E AND EIF4GI HAVE DISTINCT AND DIFFERENTIAL IMPRINTS ON MULTIPLE MYELOMA'S PROTEOME AND SIGNALING

ABSTRACT: Accumulating data indicate translation plays a role in cancer biology, particularly its rate limiting stage of initiation. Despite this evolving recognition, the function and importance of specific translation initiation factors is unresolved. The eukaryotic translation initiation complex eIF4F consists of eIF4E and eIF4G at a 1:1 ratio. Although it is expected that they display interdependent functions, several publications suggest independent mechanisms. This study is the first to directly assess the relative contribution of eIF4F components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in a malignancy known for extensive protein synthesis- multiple myeloma (MM). Previously, we have shown that eIF4E/eIF4GI attenuation (siRNA/ Avastin) deleteriously

ORGANISM(S): Homo sapiens

SUBMITTER: Metsada Pasmanik-Chor 

PROVIDER: E-GEOD-62821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress