Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Functional characterization of C. elegans Y-box binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes (RIP-Seq)


ABSTRACT: We present a basic characterization of the function of Y-box binding proteins (YBPs) in C. elegans. YBPs in other organisms are known RNA-binding proteins. Our global analysis of associated mRNAs supports a role of YBPs as general mRNA binders in C.elegans. FLAG IPs were performed on transgenic animals expressing FLAG-tagged versions of either CEY-1, CEY-2, or CEY-4. MYC IPs served as controls. All IPs were performed in duplicates. 12 samples in total.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Dimos Gaidatzis 

PROVIDER: E-GEOD-62856 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes.

Arnold Andreas A   Rahman Md Masuder MM   Lee Man Chun MC   Muehlhaeusser Sandra S   Katic Iskra I   Gaidatzis Dimos D   Hess Daniel D   Scheckel Claudia C   Wright Jane E JE   Stetak Attila A   Boag Peter R PR   Ciosk Rafal R  

Nucleic acids research 20141105 21


The cold shock domain is one of the most highly conserved motifs between bacteria and higher eukaryotes. Y-box-binding proteins represent a subfamily of cold shock domain proteins with pleiotropic functions, ranging from transcription in the nucleus to translation in the cytoplasm. These proteins have been investigated in all major model organisms except Caenorhabditis elegans. In this study, we set out to fill this gap and present a functional characterization of CEYs, the C. elegans Y-box-bind  ...[more]

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